Benfica will also be without head coach Jose Mourinho, who is suspended after receiving a red card in the first leg.
IMAGES from the UEFA Champions League matches played on Wednesday.
Miami's Hard Rock Stadium was awash in Argentine passion as Boca Juniors fans turned it into a little Buenos Aires for their team's 2-2 draw with Benfica on Monday.
IMAGES from UEFA Champions League matches played on Wednesday
Barcelona's Raphinha scored deep into stoppage time to hand his side a dramatic 5-4 comeback win at Benfica and a place in the Champions League last 16.
A round-up of Tuesday's action in the UEFA Champions League.
Premier League champions Manchester City were drawn on Thursday with Juventus, Wydad AC and Al Ain in Group G for next year's FIFA Club World Cup in the United States.
Messi had asked to be withdrawn in the reverse fixture at Benfica last week due to the calf problem but PSG boss Christophe Galtier expects him to return for the weekend clash against third-placed Olympique de Marseille.
Real Madrid will play local rivals Atletico Madrid while Bayern Munich were drawn against Bundesliga title challengers Bayer Leverkusen on Friday.
Borussia Dortmund snatched a 1-0 victory over Chelsea in the Champions League round of 16 first leg on Wednesday
'His dismissal could backfire -- not just as a PR problem, but as a crack in the BJP's coalition of castes and communities.'
A round-up of Tuesday's action in the UEFA Champions League.
Manchester City came from behind to beat Club Brugge 3-1 and secure their place in the Champions League playoffs
IMAGES from the Champions League matches played on Wednesday.
Manchester City have one just victory from their last 10 games across all competitions.
Goals from Hulk and Axel Witsel helped Zenit St Petersburg get their Champions League campaign off to the perfect start as they beat 10-man Benfica 2-0 away on Tuesday.
A first-half penalty earned Lille a shock 1-0 home victory over holders Real Madrid in the Champions League group phase on Wednesday.
IMAGES from the UEFA Champions League matches played on Wednesday
Spartak Moscow will be without leading strikers Emmanuel Emenike and Welliton for Wednesday's Champions League Group G match at Benfica, the Russian club said on Tuesday.
Real Madrid's Rodrygo struck twice and Jude Bellingham was also on target as the visitors enjoyed a 3-0 win at lowly Cadiz.
IMAGES from the UEFA Champions League matches played on Wednesday.
Images from UEFA Champions League matches played on Wednesday.
Photos from the Champions League matches played on Wednesday.
Juventus clinched a place in the Champions League knockout stages when a brilliant Cristiano Ronaldo assist set up Mario Mandzukic to give them a 1-0 win over Valencia on Tuesday.
Benfica snatched a 2-2 draw at sloppy Manchester United to reach the Champions League last 16 and leave the three-times winners with work to do, while Inter Milan ambled through before even playing and Bayern Munich also progressed with ease on Tuesday.
English Premier League side Chelsea completed the signing of Argentina midfielder Enzo Fernandez from Benfica for a British record 106.8 million pounds ($131.46 million).
The Champions League group stages took on a less predictable look after Thursday's draw, helped by UEFA's decision to tweak the seeding system.
A round-up of Wednesday's action in the UEFA Champions League.
Argentina have called up Mallorca's Spanish defender Pablo Maffeo for the first time ahead of this month's World Cup qualifiers against Uruguay and Brazil in the squad announced by its FA on Friday.
If two or more clubs are level on points at the end of the group stage, a number of criteria will be taken into consideration to decide the qualifiers for the next round, starting with the head-to-head record among the teams in question. It then goes to superior goal difference and then goals scored in those matches.
Barcelona made a disappointing start to their Champions League campaign by losing 2-1 to AS Monaco on Thursday.
A round-up of Wednesday's action in the UEFA Champions League.
Arsenal might be struggling in the Premier League but they are 100 per cent in Group B of the Europa League
Harry Kane netted his 200th goal for Tottenham Hotspur as they won 3-1 at Ludogorets and AC Milan's 24-match unbeaten run ended
Bayer Leverkusen crushed hosts VfL Bochum 5-0 to stretch their remarkable unbeaten run across all competitions this season to 50 consecutive matches.
Premier League clubs spend $1 billion for first time in January transfer window
A summary of Tuesday's Group stage matches in the UEFA Champions League.
A round-up of Tuesday's action in the UEFA Champions League.
Images from the UEFA Champions League matches on Tuesday night.
A summary of the UEFA Champions League Group Stage action, on Wednesday.
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